Respiratory Virus Infections in BMT
Community Respiratory Virus Infections in Bone
Marrow Transplant Recipients: The M.D. Anderson
Cancer Center Experience
Richard E. Champlin, Estella Whimbey
Biology of Blood and Marrow Transplantation 7:8S-10S (2001)
© 2001 American Society for Blood and Marrow Transplantation
ABSTRACT:
Community respiratory virus (CRV) infections are common among bone marrow transplant (BMT) recipients during
community outbreaks. At M.D. Anderson Cancer Center (MDACC), experience with CRV infection in this population
over the past decade suggests that BMT recipients in the preengraftment phase are at special risk of progression of
upper respiratory tract infection (URTI) to pneumonia. After pneumonia is established, no currently available therapy
substantially reduces mortality. For BMT recipients with respiratory syncytial virus URTIs, treatment with ribavirin
and intravenous immunoglobulin may be helpful in preventing progression to pneumonia and thus in reducing mortality,
but this approach requires confirmation in controlled clinical trials. Prevention of CRV infection in this vulnerable
patient population is crucial to reducing morbidity and mortality. Aggressive infection control precautions, which have
been in effect at MDACC since 1994, have reduced nosocomial transmission of these potentially lethal infections.
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