ABMT in Patients with Low-Grade or Mantle Cell Lymphoma
Allogeneic Bone Marrow Transplantation in Patients With Sensitive Low-Grade Lymphoma or Mantle Cell Lymphoma
Biology of Blood and Marrow Transplantation 7:561-567 (2001)
© 2001 American Society for Blood and Marrow Transplantation
Jesús G. Berdeja, Richard J. Jones, Marianna L. Zahurak, Steven Piantadosi, Ross A. Abrams,
Michael J. Borowitz, Georgia B. Vogelsang, Stephen J. Noga, Richard F. Ambinder, Ian W. Flinn
ABSTRACT
Purpose: To report survival outcomes of allogeneic BMT in patients with low-grade lymphoma or mantle cell lymphoma
(MCL).
Patients and Methods: Thirty-five patients with low-grade lymphoma (48%), chronic lymphocytic leukemia (26%),
or MCL (26%) underwent myeloablative allogeneic BMT from HLA-identical siblings at the Johns Hopkins Oncology
Center. Patients had a median age of 46 years, a median of 2 prior treatments, and 31% were in complete remission
at the time of transplantation. The preparative regimen was cyclophosphamide/total body irradiation for most
patients. All grafts were T-cell depleted by counter flow centrifugal elutriation with CD34+ augmentation.
Results: The incidence of acute GVHD grade >2 was 6% and of grades 1 to 2 was 37%. The incidence of chronic
GVHD was 6%. The median follow-up time was 25 months. The rate of event-free survival (EFS) was 50% (95%
confidence interval [CI], 33%-66%). Only 1 patient relapsed. The transplantation-related mortality (TRM) was 46%
for all patients. The TRM was 86% for patients with resistant disease and 14% for patients with sensitive disease
and <2 prior treatments; rates of EFS were 0% (95% CI, 0%-0%) and 79% (95% CI, 47%-93%), respectively.
Conclusion: These data show that, with T-cell depletion, the TRM and relapse rates are modest for patients with
sensitive disease and <2 prior treatment courses. Thus, if there is a role for allogeneic BMT in the management of
patients with these tumors, it is early in the course of the disease.
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