Evaluation of the Beckman Coulter AcT 5diff

An Evaluation of the Beckman Coulter Compact 5-Part Differential Hematology Analyzer AcT 5diff

Caroline Kern
Haematology Laboratory, Appensell Kantonal Hospital, Herisau, Switzerland

Laboratory Hematology 7:125-129
© 2001 Carden Jennings Publishing Co., Ltd.

The Beckman Coulter compact 5-part differential hematology analyzer, the AcT 5diff analyzer, was evaluated. It provides up to 26 parameters with a throughput of 60 samples/hour on a selectable mode: complete blood count (CBC) or CBC plus 5-part differential leukocyte count (DLC), with a minimal sampling size (53γL for CBC plus DLC and 30γL for CBC). The AcT 5diff analyzer was evaluated on the basis of a simplified protocol based on the routine workload. The sample stability was excellent for all CBC parameters (up to 72 hours) and for DLC parameters (up to 48 hours) with a slight shift on monocyte counts. Correlation coefficients for all CBC parameters were excellent for neutrophils, lymphocytes, and eosinophils and acceptable for monocytes. The clinical sensitivity of the white blood cell flagging system performed well with a sensitivity of 92.8% and a specificity of 87.2%. The instrument was easy to use and offered a sample-by-sample selection for CBC only or CBC plus DLC. 

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